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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBC1D22B
All Species:
20.91
Human Site:
Y253
Identified Species:
41.82
UniProt:
Q9NU19
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NU19
NP_060242.2
505
59081
Y253
F
G
F
I
E
Q
Y
Y
D
S
R
N
E
E
H
Chimpanzee
Pan troglodytes
XP_527375
505
59106
Y253
F
G
F
I
E
Q
Y
Y
D
S
R
N
E
E
H
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538894
488
57073
D254
T
Y
R
Q
I
H
I
D
I
P
R
T
N
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8R5A6
516
59344
Y264
F
A
F
I
E
H
Y
Y
S
S
R
N
D
E
V
Rat
Rattus norvegicus
NP_001020230
505
59036
Y253
F
G
F
I
E
Q
Y
Y
D
S
R
N
E
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509397
560
64265
Q255
S
R
N
E
E
H
H
Q
D
T
Y
R
Q
I
H
Chicken
Gallus gallus
XP_419261
747
85990
Y495
F
G
F
I
Q
Q
Y
Y
D
S
R
N
E
E
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_685523
523
60664
Y271
F
G
F
I
E
Q
Y
Y
H
S
R
T
D
E
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650941
546
61493
F289
Q
D
L
R
H
N
Y
F
R
V
D
S
Q
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023165
495
56525
I253
D
T
F
R
Q
I
N
I
D
I
P
R
M
C
P
Sea Urchin
Strong. purpuratus
XP_797601
498
57012
D255
M
F
H
Q
I
H
I
D
I
P
R
T
N
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08484
637
73271
F323
R
D
S
L
K
H
T
F
S
D
Q
H
S
R
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
95.4
N.A.
62.2
98.4
N.A.
79.6
63.3
N.A.
70.1
N.A.
43
N.A.
46.9
46.7
Protein Similarity:
100
100
N.A.
96
N.A.
76.7
99
N.A.
83.5
65.1
N.A.
81.6
N.A.
57.6
N.A.
62.1
65.5
P-Site Identity:
100
100
N.A.
6.6
N.A.
66.6
100
N.A.
20
93.3
N.A.
73.3
N.A.
6.6
N.A.
13.3
6.6
P-Site Similarity:
100
100
N.A.
6.6
N.A.
73.3
100
N.A.
40
100
N.A.
86.6
N.A.
33.3
N.A.
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
9
17
0
0
0
0
0
17
50
9
9
0
17
9
9
% D
% Glu:
0
0
0
9
50
0
0
0
0
0
0
0
34
50
9
% E
% Phe:
50
9
59
0
0
0
0
17
0
0
0
0
0
0
0
% F
% Gly:
0
42
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
9
0
9
42
9
0
9
0
0
9
0
0
42
% H
% Ile:
0
0
0
50
17
9
17
9
17
9
0
0
0
9
0
% I
% Lys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
9
0
0
0
0
0
0
0
0
0
0
17
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
9
0
0
9
9
0
0
0
0
42
17
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
17
9
0
0
17
9
% P
% Gln:
9
0
0
17
17
42
0
9
0
0
9
0
17
0
0
% Q
% Arg:
9
9
9
17
0
0
0
0
9
0
67
17
0
9
0
% R
% Ser:
9
0
9
0
0
0
0
0
17
50
0
9
9
0
0
% S
% Thr:
9
9
0
0
0
0
9
0
0
9
0
25
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
59
50
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _